Related Products of 14160-93-1 ,Some common heterocyclic compound, 14160-93-1, molecular formula is C5H4ClN3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A solution of 4-amino-6-chloropyrimidine-5-carbaldehyde (F1) (7.62 mmol, 1.2 g) was dissolved in a mixture of 25 ml of glacial acetic acid and 4 ml of water,Methoxyamine hydrochloride (13.71 mmol, 1.14 g) was added,The reaction was carried out at 25 C overnight.After completion of the reaction, 20 ml of water was added to the reaction mixture, and the mixture was extracted with 50 ml of ethyl acetate. The organic layer was washed with water 3 times, 10% sodium hydroxide solution and saturated brine, dried over anhydrous magnesium sulfate, The solvent was distilled off and purified by column chromatography (eluent petroleum ether: ethyl acetate = 3: 1) to give a white solid in 99% yield.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 14160-93-1, 4-Amino-6-chloropyrimidine-5-carbaldehyde, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Shan Dong University; Zhao, Guisen; Lu, Jinjie; Wang, Guanjie; Yang, Dezhi; Zhang, Zhen; Jing, Yongkui; (32 pag.)CN106045918; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia