In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1445-39-2, name is 2-Amino-5-iodopyrimidine, the common compound, a new synthetic route is introduced below. Formula: C4H4IN3
NaH (0.7 lg, 17.9mmol) was added to a solution of 5-iodopyrimidin-2-amine (2g, 8.9mmol) at 0 C and stirred the reaction mixture for 15min. Added 2-fluoro-l-methyl-3-nitrobenzene (1.52g, 9.8mmol) and stirred the reaction mass at room temperature. Cooled the reaction mass to 0 C and quenched with ice cold water and ethyl acetate. Separated ethyl acetate layer washed with water followed by brine, dried over Na2S04, filtered and concentrated. The residue was purified by 60-120 silica gel column chromatography to afford desired title compound (3g, 90%). LCMS: m/z = 357.0 (M+H)+.
The synthetic route of 1445-39-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; EISAI R & D MANAGEMENT CO., LTD.; REYNOLDS, Dominic; HAO, Ming-Hong; WANG, John; PRAJAPATI, Sundeep; SATOH, Takashi; SELVARAJ, Anand; (128 pag.)WO2016/164703; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
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