Application of 160199-05-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.160199-05-3, name is 2,4-Dichlorobenzo[4,5]thieno[3,2-d]pyrimidine, molecular formula is C10H4Cl2N2S, molecular weight is 255.1232, as common compound, the synthetic route is as follows.
70.0 g (274.4 mmol) of Intermediate B, 33.5 g (274.4 mmol) of phenylboronic acid, 94.8 g (686.0 mmol) of potassium carbonate, and 15.9 g (13.7 mmol) of tetrakis (triphenylphosphine) palladium (0) were added to 800 mE of 1 ,4-dioxane and 400 mE of water in a 2000 mE flask, and the mixture was heated under a nitrogen flow for 24 hours at 50 C. The obtained mixture was added to 3000 mE of methanol, and a solid crystallized therein was filtered, dissolved in monochlorobenzene, filtered with silica gel/Celite, and then, recrystallized with methanol afier removing an appropriate amount of an organic solvent to obtain Intermediate 13-2-1 (59.4 g, yield of 73%). calcd. C16H9C1N2S: C, 64.75; H, 3.06; Cl, 11.95; N, 9.44; 5, 10.80; found: C, 64.70; H, 3.02; Cl, 11.93; N, 9.40; 5, 10.73.
The chemical industry reduces the impact on the environment during synthesis 160199-05-3, I believe this compound will play a more active role in future production and life.
Reference:
Patent; SAMSUNG SDI CO., LTD.; KANG, Dong Min; KIM, Youngkwon; KIM, Changwoo; YU, Eun Sun; LEE, Byoungkwan; LEE, Hanill; JUNG, Sung-Hyun; JEONG, SooYoung; JUNG, Ho Kuk; (72 pag.)US2018/26205; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia