The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1683-75-6, name is 2-Amino-4-chloro-5-fluoropyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 2-Amino-4-chloro-5-fluoropyrimidine
To a solution of 6-bromo-4-methoxy-lH-indole-3-carbaldehyde A.140 (0.65 g, 2.56 mmol) in DMF (13 mL) at room temperature was added Cs2CO3 (2.50 g, 7.67 mmol) followed by 4-chloro-5-fluoropyrimidin-2-amine A.53 (0.453 g, 3.07 mmol) and the mixture was stirred at 80 0C for 6 hours. The mixture was concentrated under reduced pressure and purified by silica gel column chromatography using 0% to 100% gradient of dichloromethane-methanol- NH4OH (89:9:1) in dichloromethane as eluent to give l-(2-amino-5-fiuoropyrimidin-4-yl)-6- bromo-4-methoxy-lH-indole-3-carbaldehyde A.141 (0.319 g, 34.2% yield) as a yellow solid: 1H NMR (500 MHz, DMSO-d6) 5 ppm 10.39 (1 H, s), 8.56 (1 H, d, J=3.7 Hz), 8.32 (1 H, d, J=2.7 Hz), 7.95 (1 H, s), 7.13 (2 H, s), 7.12 (1 H, d, J=1.4 Hz), 4.01 (3 H, s); Mass Spectrum(ESI) m/e = 365.0 [M+l ( 79Br] and 367.0 [M+l (81Br)].
With the rapid development of chemical substances, we look forward to future research findings about 1683-75-6.
Reference:
Patent; AMGEN INC.; WO2009/158011; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia