Electric Literature of 18592-13-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 18592-13-7, name is 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione. A new synthetic method of this compound is introduced below.
Intermediate 1 y)methyl)pyrimidine-2,4(lH,3H)-dione A mixture of 6-(chloromethyl)pyrimidine-2,4(lH,3H)-dione (1 g, 6.23 mmol), 2,2,2- trifluoroethanol (2.235 mL, 31.14 mmol) and cesium carbonate (6.09 g, 18.68 mmol) in dimethylformamide (10 mL) was heated in a microwave oven at 100C for 30 min. The mixture was filtered and the volatiles were removed in vacuum. The residue was treated with diluted HCI (pH 4.5) and cooled to 0C. The resulting crystalls were collected by fitration and dried in vacuum cabinet to yield the title compound, 0.92 g (66%). MS (APCI ) m/z 223 (M-H) XH NMR (500 MHz, DMSO-cf6) 0 ppm 4.18 (q, 2 H) 4.36 (s, 2 H) 5.49 (s, 1 H) 10.93 (br. s., 1 H) 11.03 (br. s., 1 H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,18592-13-7, its application will become more common.
Reference:
Patent; ACTURUM LIFE SCIENCE AB; BESIDSKI, Yevgeni; YNGVE, Ulrika; PAULSEN, Kim; LINDE, Christian; MACSARI, Istvan; MALMBORG, Jonas; PAPTCHIKHINE, Alexander; ARVIDSSON, Per; WO2014/195323; (2014); A1;,
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