Related Products of 13877-56-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.13877-56-0, name is 1H-Pyrazolo[4,3-d]pyrimidin-7-amine, molecular formula is C5H5N5, molecular weight is 135.13, as common compound, the synthetic route is as follows.
1H-Pyrazolo[4,3-d]pyrimidin-7-amine (82% pure, 2.85 g, 17.3 mmol) in N,N-dimethylformamide (40 mL) was treated with N-iodosuccinimide (3.8 g, 16.9 mmol). The mixture was heated in an 80 C. oil bath for 1.5 hours then cooled and concentrated under reduced pressure. Ethanol (20 mL) and water (10 mL) was added to the residue then stirred and cooled in an ice bath. The precipitate was collected by filtration and washed with water. The filtrate was concentrated under reduced pressure then water (20 mL) was added and the solid was again collected by filtration and washed with water. The solids thus isolated were combined and dried under high vacuum to give the desired title compound as a brown powder: 1H NMR (DMSO-d6, 400 MHz) delta13.2 (s, 1H), 8.21 (s, 1H), 7.39 (bs, 2H); RP-HPLC (Hypersil HS C18, 5 mum, 100A, 250×4.6 mm; 5%-100% acetonitrile-0.05 M ammonium acetate over 25 min, 1 mL/min) tr 8.58 min; MS:MH+ 262.0, M-H+ 259.9
The chemical industry reduces the impact on the environment during synthesis 13877-56-0, I believe this compound will play a more active role in future production and life.
Reference:
Patent; Hirst, Gavin C.; Arnold, Lee D.; Burchat, Andrew; Wishart, Neil; Calderwood, David; Wada, Carol K.; Michaelides, Michael R.; Ji, Zhiqin; Muckey, Melanie; US2003/225098; (2003); A1;,
Pyrimidine | C4H4N2 – PubChem,
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