Adding a certain compound to certain chemical reactions, such as: 16019-33-3, 2-(4,6-Dichloropyrimidin-5-yl)acetaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 2-(4,6-Dichloropyrimidin-5-yl)acetaldehyde, blongs to pyrimidines compound. name: 2-(4,6-Dichloropyrimidin-5-yl)acetaldehyde
Example 12Preparation of Compound 9Step 1 – Synthesis of compound 12A; 2-Fluoro-4-sulfonylmethyl aniline (0.104 g, 0.55 mmol) was cooled to -15 0C, then was diluted with TFA (0.55 mL, 7.4 mmol) and the resulting solution was allowed to stir for 30 minutes. Sodium triacetoxyborohydride (2.75 mmol) was then added portionwise and the resulting reaction was allowed to stir for an additional 30 minutes. To this reaction mixture was added a solution of compound 3 (0.1 g, 0.523 mmol) in dichloromethane (1.0 mL) and the resulting reaction was allowed to stir for 15 hours. The organic layer was collected and extracted with dichloromethane, and the dichloromethane was then washed with saturated aqueous sodium bicarbonate solution, dried over MgSO4, filtered and concentrated in vacuo. The residue obtained was purified using flash column chromatography on silica gel (30% acetone / hexanes) to provide compound 12 A (0.133 g, 69%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,16019-33-3, 2-(4,6-Dichloropyrimidin-5-yl)acetaldehyde, and friends who are interested can also refer to it.
Reference:
Patent; SCHERING CORPORATION; NEELAMKAVIL, Santhosh, Francis; BOYLE, Craig, D.; CHACKALAMANNIL, Samuel; GREENLEE, William, J.; WO2010/9195; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia