Related Products of 831203-15-7 ,Some common heterocyclic compound, 831203-15-7, molecular formula is C6H4BrN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Add acetic anhydride (2.50 g, 23.7 mmol) to a solution of2-(5-bromopyrimidin-2yl)acetonitrile (950 mg, 4.75 mmol) and triethyl orthoformate (3 mL, 17.7 mmol), the reaction mixture is stirred at 120 oc for 5 h. The reaction mixture is concentrated to afford 10 title compound (0.96 g, 79.6%) as brown crude. LCMS (m/z): 255.9 [M+Ht.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 831203-15-7, 2-(5-Bromopyrimidin-2-yl)acetonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ELI LILLY AND COMPANY; LILLY CHINA RESEARCH AND DEVELOPMENT CO., LTD.; MA, Tianwei; WU, Liang; ZHANG, Xuejun; (109 pag.)WO2019/41340; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia