As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 111196-81-7, name is 2-Chloro-5-ethylpyrimidine, molecular formula is C6H7ClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of 2-Chloro-5-ethylpyrimidine
4-{2-[(5-Ethylpyrimidin-2-yl)amino]ethyl}phenol; Tyramine (5.52 g, 0.040 mol) in 40 ml of anhydrous DMF was treated with diisopropylethylamine (6.1 ml, 0.035 mol). After stirring at rt for 15 minutes, 2-chloro-5- ethylpyrimidine (4.25 ml, 035 mol) was added and the mixture heated at 80C for 14 hours. The solution was allowed to cool to room temperature and was partitioned between equal volumes of water and ethyl acetate. The aqueous phase was washed with ethyl acetate and the combined organic phases were dried over MgSO4 and concentrated. The residue was purified by flash chromatography eluting with 40% ethyl acetate-hexane to afford the title compound as a colorless solid 949 ; 58% 1H NMR (CDCl3) No. 1.20 (t, 3H, J=7.6); 2.46 (q, 2H, J=7.6); 2.83 (t, 2H, J=6.3); 3.515 (s, 1H); 3.63 (q, 2H, J=6.3); 5.14 (br s, 1H); 6.70 (d, 2H, J=8.4); 7.02 (d, 2H, J=8.3), 8.19 (s, 2H). MS: m/z 244 (M+1).
With the rapid development of chemical substances, we look forward to future research findings about 111196-81-7.
Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2003/74495; (2003); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia