Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 69034-12-4, name is 2-Chloro-5-(trifluoromethyl)pyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C5H2ClF3N2
N,N-Diisopropylethylamine (30 mu, 0.2 mmol) is added to a stirred solution of example 62a (35 mg, 0.2 mmol) and 2-Chloro-5-(Trifluoromethyl)pyrimidine (36 mg, 0.2 mmol) dissolved in 1 ml of anhydrous DMSO; the reaction is heated in a microwave reactor during 2 hours at 100 C. Water and EtOAc are added to the crude, the organic phase is separated, washed with water, dried and concentrated under reduced pressure. The residue is purified by Silica gel flash chromatography, using DCM/MeOH 100:2 as eluent, to obtain the title compound (30 mg, 47% yield). UPLC-MS (Method 1): Rt = 0.90 min MS (ES+): m/z = 327 [M+H]+ . Chiral HPLC (Method 15): Rt = 4.38 min
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Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; HOENKE, Christoph; GIOVANNINI, Riccardo; LESSEL, Uta; ROSENBROCK, Holger; SCHMID, Bernhard; WO2015/55698; (2015); A1;,
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