Adding a certain compound to certain chemical reactions, such as: 22536-66-9, 2-Chloropyrimidine-4-carboxamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 2-Chloropyrimidine-4-carboxamide, blongs to pyrimidines compound. name: 2-Chloropyrimidine-4-carboxamide
4.3. 2-[{3-[4-{[5-Methyl-2-(1-methylethyl)phenoxy]methyl}-1-piperidyl]-propyl}amino]pyrimidine-4-carboxamide 4.4 g (0.0144 mol) of 4-{[5-methyl-2-(1-methylethyl)phenoxy]methyl}-1-piperidinepropanamine hydrochloride, 2.27 g (0.0144 mol) of 2-chloropyrimidine-4-carboxamide and 2.98 g (0.0216 mol) of K2 CO3 in 86 ml of DMF are reacted. The mixture is stirred for 48 h. It is poured into water and then extracted 3 times with AcOEt. The organic phase is washed 3 times with water. It is dried over Na2 SO4, filtered and concentrated. The product crystallises. It is taken up in a little ether and the mixture is filtered. 4.5 g (0.0105 mol) of base are obtained, which base is taken up in 100 ml of EtOH and a solution of 1.22 g (0.0105 mol) of fumaric acid in 150 ml of EtOH is added. M.p. 183-88 C. Yield: 36%.
The synthetic route of 22536-66-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Synthelabo; US5210086; (1993); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia