Electric Literature of 22276-95-5 , The common heterocyclic compound, 22276-95-5, name is 5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine, molecular formula is C6H3BrClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of 5-bromo-4-cUoro-7H-pyrrolo[2 -d]pyrirnidine D3 (l.OOg) inDMF (10 mL) at 0 C was added sodium hydride (0.224 g, 5.59 mmol) and the mixture stirred for 20 minutes, Benzenesulfonyl chloride (0.66 mL, 5.16 mmol) was then added dropwise and the reaction mixture stirred in the cool bath for 1 hour. The mixture was poured onto water (140 mL) and the precipitate filtered, washed with water and dried in a vacuum oven to give D5 (1.60 g) as an off white solid, lH NMR (CDC13) delta 8.77 (1H, s), 8.23 (2H, dd), 7.85 (1H, s), 7.70 (1H, m), 7.59 (2H, ddd), MS(ES+) 372 [M(Ci2H779Br35Cl 302S)+H]+. The crude product was used without further purification into the preparation of D6..
The synthetic route of 22276-95-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CONVERGENCE PHARMACEUTICALS LIMITED; WITTY, David R.; NORTON, David; TIERNEY, Jason Paul; LORTHIOIR, Ghislaine; SIME, Mairi; PHILPOTT, Karen Louise; WO2012/80735; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
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