Reference of 22536-65-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.22536-65-8, name is 2-Chloro-5-methoxypyrimidine, molecular formula is C5H5ClN2O, molecular weight is 144.56, as common compound, the synthetic route is as follows.
To (1 -(3-(difluoromethyl)phenyl)-5-methyl-1 H-i 2,3- triazol-4-yl)methanol (45 mg, 0.19 mmol) stirring in THF (1 mL) was added NaH (60percent dispersion in mineral oil, 22.6 mg, 0.56 mmol) and the reaction wasstirred for 5 mi 2-Chloro-5-methoxypyrimidine was then added and the reaction was stirred at rt for 1 h. The reaction was quenched with H20, then diluted with EtOAc and H20. The layers were separated and the aqueous layer was extracted with EtOAc (3X). The combined organic layers were washed with H20 (ix), brine (ix), then dried (Na2504) and concentratedunder reduced pressure. Purification (FCC, 5i02, EtOAc/hexanes 0 – 60percent)afforded the title compound (41 mg, 62percent). MS (ESI): mass calcd. forC15H15F2N502, 347.1; m/zfound, 348.0 [M+H]. 1H NMR (400 MHz, CDCI3) O8.24 (5, 2H), 7.71 ? 7.56 (m, 4H), 6.73 (t, J = 56.1 Hz, 1 H), 5.56 (5, 2H), 3.88(5, 3H), 2.45 (5, 3H).
The chemical industry reduces the impact on the environment during synthesis 22536-65-8, I believe this compound will play a more active role in future production and life.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; CHEN, Gang; CHROVIAN, Christa C.; COATE, Heather R.; DVORAK, Curt A.; GELIN, Christine F.; HISCOX, Afton; LETAVIC, Michael A.; RECH, Jason C.; SOYODE-JOHNSON, Akinola; STENNE, Brice; WALL, Jessica L.; ZHANG, Wei; (583 pag.)WO2017/139428; (2017); A1;,
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