Related Products of 14048-15-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.14048-15-8, name is 2,4-Dimethoxypyrimidin-5-amine, molecular formula is C6H9N3O2, molecular weight is 155.16, as common compound, the synthetic route is as follows.
General Procedure for Synthesis; General procedure for 4-Aza-2,3-didehydropodophyllotoxin Sythesis (1). A mixture of substituted heteroaromatic amines (1 eq ), tetronic acid (1 eq), and a corresponding substituted aromatic aldehydes (1 eq) in EtOH (4 mL) was refluxed at temperature 78 oC for 1 h. The reaction mixture was allowed to cool to room temperature 25 oC. and the precipitated product was collected by vacuum filtration and washed with EtOH (3 mL) at room temperature 25 oC and then recrystallized with ethanol (15 mL and 78 oC) to give pure compounds in 90 – 98 % yield in all case.Example 12,4-dimethoxy-5-(3,4,5-trimethoxyphenyl)-5,6,8,9tetrahydrofuro[3′,4′:5,6]pyrido[2,3-iflpyrimidin-6-one (4a). This compound was prepared by method described above employing 3,4,5-trimethoxybenzaldehyde (200 mg, 1.020 mmol), tetronic acid (102 mg, 1.020 mmol) and 2,4-dimethoxypyrimidine-5-amine (158 mg, 1.020 mmol) to affords 4a, 390 mg in 92% yield. Mp: 299-300 C, NMR (200 MHz, DMSO-d6): (53.61 (s, 3H), 3.70 (s, 6H), 3.81 (s, 3H), 3.85 (s, 3H), 4.79-5.02 (m, 3H), 6.43 (s, 2H), 10.61 (s,lH); 13C NMR (75 MHz, DMSO-d6): £34.3, 53.8, 54.3, 55.7, 59.7, 65.2, 93.8, 99.6, 104.7, 136.1, 139.9, 152.4, 156.8, 163.2, 168.8, 171.1; MS (ESI): 416 [M++H]; HRMS (ESI) calcd for C20H22N3O7 ([M+Na]+) 416.1457; found: 416.1447.
Statistics shows that 14048-15-8 is playing an increasingly important role. we look forward to future research findings about 2,4-Dimethoxypyrimidin-5-amine.
Reference:
Patent; COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH; AHMED, Kamal; PAIDAKULA, Suresh; BANALA, Ashwini, Kumar; ADLA, Mallareddy; PAPAGARI, Venkat, Reddy; JAKI, Rasheed, Tamboli; WO2012/76942; (2012); A1;,
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