Electric Literature of 74356-36-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 74356-36-8, name is 2,4-Dimethyl-pyrimidine-5-carboxylic acid. This compound has unique chemical properties. The synthetic route is as follows.
The compound of Reference Example 56 (253mg, 1.00mmol) and 2,4-dimethylpyrimidine-5-carboxylic acid (152mg, 1.00mmol) and 1-hydroxybenzotriazole (135mg, 1.00mmol) and 1-(3 dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (230 mg, 1.20 mmol) and triethylamine (418muL, 3.00mmol) and a mixture of N,N-dimethylformamide (2 mL) was stirred at room temperature for 16 hours. Thereafter, the reaction mixture was purified by directly preparative high-performance liquid column chromatography. Then the obtained product (157mg, 0.50mmol) in tetrahydrofuran (5.0 mL) lithium aluminum hydride (56.9mg, 1.50mmol) of was added at 10 C. After 16 hours with stirring at 10C , the water and 10% sodium hydroxide solution was added, the precipitate was removed by Celite filtration, and the filtrate was concentrated. The resulting concentrated residue was purified by preparative high-performance liquid column chromatography, to give the title compound (4%).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 74356-36-8, 2,4-Dimethyl-pyrimidine-5-carboxylic acid.
Reference:
Patent; SUMITOMO DAINIPPON PHARMA COMPANY LIMITED; YOSHINAGA, HIDEFUMI; URUNO, YOSHIHARU; NAGATA, HIDETAKA; HASHIMOTO, MASAKAZU; KATO, TARO; (82 pag.)JP2016/108326; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
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