Synthetic Route of 2434-53-9 , The common heterocyclic compound, 2434-53-9, name is 6-Amino-1-methylpyrimidine-2,4(1H,3H)-dione, molecular formula is C5H7N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: Appropriate indole of 1.0 equiv, 1.1 equiv of the corresponding aminoheterocycle, and 4 equiv of TMSCl in 15 mL of anhydrous DMF was heated at 100 C under dry argon atmosphere in a pressure tube. After 6 h the solvent was removed under reduced pressure and the residue was purified by silica gel flash chromatography.
The synthetic route of 2434-53-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Knepper, Ingo; Iaroshenko, Viktor O.; Vilches-Herrera, Marcelo; Domke, Lutz; Mkrtchyan, Satenik; Zahid, Muhammad; Villinger, Alexander; Langer, Peter; Tetrahedron; vol. 67; 29; (2011); p. 5293 – 5303;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia