Adding a certain compound to certain chemical reactions, such as: 55583-59-0, 2,5-Diamino-4,6-dichloropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C4H4Cl2N4, blongs to pyrimidines compound. Formula: C4H4Cl2N4
In a reaction vessel, 4,6-dichloropyrimidine-2,5-diamine (1.00 g, 5.59 mmol),4- (N, N-Dimethylamino) phenylboronic acid(0.922 g, 5.5 9 mmol),Sodium carbonate (2.96 g, 27.9 mmol),To a solution of tetrakis (triphenylphosphine) palladium (0) (0.323 g, 0.560 mmol) in toluene (56 mL) was added ethanol (14 mL) and distilled water (14 mL) at room temperature, and then under an argon atmosphere. After stirring for 20 hours under heating and reflux conditions, the reaction solution was cooled to room temperature. Distilled water (16 mL) was added and stirred, and the separated aqueous layer was extracted three times with ethyl acetate (20 mL).Thereafter, the whole organic layer was combined, saturated aqueous sodium chloride solution (20 mL) was added thereto, the mixture was stirred and washed, anhydrous sodium sulfate was added to the separated organic layer for dehydration, and the filtrate after filtration was concentrated under reduced pressure .The concentrate thus obtained is purified by flash column chromatography (silica gel, n-hexane / ethyl acetate),4-Chloro-6- (4- (dimethylamino) phenyl) pyrimidine-2,5-diamine(0.727 g, 49% yield).
The synthetic route of 55583-59-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Microbial Chemistry Research Foundation; Kumagai, Naoya; Noda, Hidetoshi; Asada, Yasuko; Shibazaki, Masakatsu; (48 pag.)JP2019/64981; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia