Synthetic Route of 59864-30-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 59864-30-1, name is 2,6-Dimethoxypyrimidine-4-carboxylic acid. This compound has unique chemical properties. The synthetic route is as follows.
General procedure: To a solution of 39b (278 mg, 0.47 mmol) in DMF (5.0 mL) wereadded 4,6-dimethoxypyrimidine-2-carboxylic acid (103 mg,0.56 mmol), DIPEA (160 muL, 0.93 mmol) and HATU (236 mg,0.62 mmol) in an ice-water bath. After stirring at room temperatureovernight, the mixture was quenched with NaHCO3 aq. and extractedwith CHCl3. The organic layer was washed with brine, dried overMgSO4 and concentrated in vacuo. The residue was purified by columnchromatography on silica gel (CHCl3/MeOH/28% NH3 aq.=100:0:0 to90:9:1). EtOAc/IPE was added to the residue, and the resulting precipitatewas filtered and dried. To the precipitate was added EtOH/EtOAc/MeCN, and the mixture was heated to 100 C. After cooling toroom temperature, the resulting precipitate was filtered and dried togive the product (96 mg, 27%) as a colorless solid. 1H NMR (DMSO-d6):delta 0.90 (3H, t, J = 7.2 Hz), 1.46-1.61 (2H, m), 1.74-1.86 (2H, m), 2.14(3H, s), 2.20-2.58 (11H, m), 2.74-2.85 (2H, m), 3.25-3.39 (2H, m),3.67 (3H, s), 4.03 (6H, s), 6.48 (1H, s), 6.82 (1H, d, J = 8.4 Hz),7.16-7.29 (3H, m), 7.51-7.62 (2H, m), 7.77 (1H, dd, J = 7.9, 1.5 Hz),8.13 (1H, s), 8.74-8.87 (1H, m), 9.14 (1H, br s), 9.27 (1H, s), 10.14(1H, br s); MS (ESI) m/z [M+H]+ 762; Anal. Calcd forC36H47N11O6S·1.7H2O: C, 54.56; H, 6.41; N, 19.44; S, 4.05. Found: C,54.55; H, 6.38; N, 19.45; S, 4.02.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 59864-30-1, 2,6-Dimethoxypyrimidine-4-carboxylic acid.
Reference:
Article; Amano, Yasushi; Echizen, Yuka; Hirano, Masaaki; Hisamichi, Hiroyuki; Iikubo, Kazuhiko; Iwai, Yoshinori; Kameda, Minoru; Kawamoto, Yuichiro; Kikuchi, Shigetoshi; Kondoh, Yutaka; Kuriwaki, Ikumi; Moritomo, Hiroyuki; Noda, Atsushi; Suzuki, Tomoyuki; Tateishi, Yukihiro; Tomiyama, Hiroshi; Bioorganic and medicinal chemistry; (2020);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia