Adding a certain compound to certain chemical reactions, such as: 26452-81-3, 4-Chloro-6-methoxypyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 26452-81-3, blongs to pyrimidines compound. Product Details of 26452-81-3
General procedure: Compound 5b (284 mg, 0.58 mmol), bromobenzene (0.08 mL, 0.75 mmol), and Pd(PPh3)2Cl2 (40 mg, 0.06 mmol)were added to a flask containing a magnetic stir with EtOH (5.80 mL). Triethylamine (0.18 mL, 1.28 mmol) was then added to the reaction mixture and the reaction mixture was stirred under reflux condition for 10 h under a N2 atmosphere. After cooling the mixture to room temperature, solvent was removed in vacuo. The crude material was diluted with ethyl acetate (5.00 mL) and water (5.00 mL). The aqueous layer was separated from the organic layer, and the aqueous layer was extracted with ethyl acetate (2 ¡Á 15 mL). Organic layers were then combined, washed with brine solution, and dried with MgSO4, and solvent was removed in vacuo. The crude material was then purified by flash column chromatography on silica gel using n-hexane/ethyl acetate = 1:1 as the eluent to give the desired product 8a as a white solid (m.p. 180 ¡ãC) in 57percent yield (146 mg); white solid; 1H-NMR (Bruker AC-600 FT-NMR spectrometer at 600 MHz, CD3OD-d4) delta ppm 7.47?7.19 (m, 12H), 7.07 (s, 1H), 6.96(d, J = 7.8 Hz, 1H), 6.15 (s, 0.77H), 5.68 (br, 0.23H), 4.75 (q, J1 = 115.8, J2 = 18.0, 2H), 3.65 (m, 1H),2.11 (s, 3H), 1.82?1.08 (m, 10H); 13C-NMR (Bruker AC-600 FT-NMR spectrometer at 150.9 MHz, CD3OD-d4) delta ppm 175.41, 171.51, 142.75, 142.33, 140.03, 136.65, 131.20, 130.26, 130.00, 129.93,129.72, 128.56, 128.15, 126.67, 126.21, 125.77, 63.73, 51.35, 50.19, 33.63. 26.75, 26.25, 26.20, 22.72; HRMS (ESI, positive ion) (m/z): [M+H]+ calcd for C29H32N2O2, 441.2543; found, 441.2542.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,26452-81-3, 4-Chloro-6-methoxypyrimidine, and friends who are interested can also refer to it.
Reference:
Article; Chung, Sheng-Hsuan; Lin, Ting-Ju; Hu, Qian-Yu; Tsai, Chia-Hua; Pan, Po-Shen; Molecules; vol. 18; 10; (2013); p. 12346 – 12367;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia