Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 29133-99-1, name is 4,6-Dichloro-2,5-diphenylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows. name: 4,6-Dichloro-2,5-diphenylpyrimidine
General procedure: Intermediate 1-4 (5.0 g, 0.009 mol) in 2-methylpyrimidin-4-ylboronic acid (3.0 g, 0.021 mol), Pd (pph3) 4 (0.5 g, 0.0005 mol), potassium carbonate (2.5 g, into a 110 mL THF to 0.018 mol), on reaction with stirring for 18 hours at 65 It turned on. After the reaction cooled to H20: delamination after column purification (n-Hexane: MC) in MC by Compound 130 to 3.8 g (71%) to give Respectively. Intermediates 33-2 (3.0 g, 0.010 mol) to 4, 6-diphenyl-1, 3, 5-triazin-2-ylboronic acid (3.2 g, 0.012 mol) in the embodiment 1-manufacturing e.g. for inserting and removing (5) the same method used in synthesis of intermediate that is 33-3 3.6g (m/z=497) is obtained (yield 73%)
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Reference:
Patent; PNH TECH; HYUN, SEO YONG; JUNG, SUNG OUK; LEE, RI NA; (142 pag.)KR2015/124637; (2015); A;,
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