Adding a certain compound to certain chemical reactions, such as: 2927-71-1, 2,4-Dichloro-5-fluoropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 2927-71-1, blongs to pyrimidines compound. category: pyrimidines
A solution of isopropylamine (2.66 mL, 29.95 mmol) and DIPEA (5.16 mL, 29.95 mmol) in THF (50 mL) was stirred at -10 C., while 2,4-dichloro-5-fluoropyrimidine (5 g, 29.95 mmol) was added portion wise. The resulting mixture was stirred at ambient temperature overnight. The mixture was diluted with 100 mL ethyl acetate and 50 mL diisopropylether. This solution was twice washed with water. The organic phase was dried over MgSO4, filtered and evaporated, yielding 67. The residue was used as such. LC-MS ES+ m/z=189; Rt: 1.65 min, method B.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2927-71-1, its application will become more common.
Reference:
Patent; Janssen Sciences Ireland UC; JONCKERS, Tim Hugo Maria; MC GOWAN, David Craig; RABOISSON, Pierre Jean-Marie Bernard; EMBRECHTS, Werner Constant Johan; GUILLEMONT, Jerome Emile Georges; (42 pag.)US2017/253600; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia