Synthetic Route of 130049-82-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 130049-82-0, name is 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidine-4-one, molecular formula is C11H15ClN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To the 250 ml three-necked bottle, add ethanol (100 mL) at room temperature.HW03602-4 (24.2 g, 46 mmol) and 6N HCl or trifluoroacetic acid (50 mL).Then, the reaction system was stirred at room temperature overnight.Depressurization gave a white solid HW03602-5 (~ 20 g, yield 100%).Used directly in the next step. Preparation of target compound HW03602: Steps 1-4 of Reference Example 1 To a 100 ml three-necked bottle at room temperature: methanol (50 mL), HW03602-5 (4.6 g,10.8 mmol), HW036-6 (2.62 g, 10.8 mmol) and N,N-diisopropylethylamine (4.2 g, 32.4 mmol). Then, will be the oppositeThe system should be heated to reflux and stirred overnight. The solvent was evaporated to dryness, and water (100 mL) was applied and ethyl acetate (3×100mL)The organic phase is extracted, washed with saturated brine, dried over anhydrous sodium sulfate, filtered, and evaporated to give a solid.Crystallization gave a white solid HW03602 (2.87 g, yield 42%).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 130049-82-0, 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidine-4-one.
Reference:
Patent; Shanghai Kezhen Pharmaceutical Technology Co., Ltd.; Dong Huanwen; Zhang Lurong; (55 pag.)CN109748914; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia