302964-08-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 302964-08-5 as follows.
heating intermediate VII (50g, 0.126mol), n-butyl alcohol (500 ml), 1-(2-hydroxyethyl) piperazine (80g, 0.614mol), and DIPEA (40g, 0.31mol) to 118 degrees reflux 8h, is gradually cooled to room temperature, then cooling to 10 degrees, filtering, 60 ml butanol washing the filter cake 2 times, drying, drying the product, get 55.3g white crystal.
The chemical industry reduces the impact on the environment during synthesis 302964-08-5, I believe this compound will play a more active role in future production and life.
Reference:
Patent; Jiangsu Chiatai Qingjiang Pharmaceutical Co., Ltd; CHEN, JIE; WANG, WUWEI; HE, JIA; (8 pag.)CN103420999; (2016); B;,
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