The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 31462-58-5, name is 5-Iodopyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 31462-58-5
A mixture of Example 5d (0.300 g, 0.618 mmol), 5-iodopynmidine (0382 g, 1.353 mmo-i cesium carb onate (0.403 g, 1 36 mmol), dicyclohexyli^^’^-triisopropyl-tl,’- bipher^2-yl)phosphine (XPhos)(0.147 g, 0.309 mmo and palladium (Pi) acetate (0035 g, 0.154 mmol) in toluene ( 12 mL) and ter i-tutanol (3 mL) under argonwas heated in a sealed tube in a rraciowave reactor at 160 * C for 1 hour. The reaction mixture was cooled to amb ient tenperature and filtered tluDugh filter paper. The resulting filtrate was concentrated to near dryness and mixed with ethanol ( 10 mL), dioxane (20 mL j, and excess 5N s odium hydroxide solution ( 10 niL). The reaction mixture: was stirred at ant ient temperature for 1 hour and then concentrated to 5 niL and partitioned between s aturated anmionium chloride aqueous solution and ethyl acetate . The aqueous phase was extracted once more with ethyl acetate. The combined organic layers were was hed with s aturated aqueous sodium cliloride, dried over ar-hydro s mag esi m sulfate, filtered, and concentrated. The res idue was purified by flash column chromatograp ^ on s ilica gel elating with 5 % methanol in dichlorortrethane to afford the title conpou d (0.066 g, 0.1 1 mmol, 26 % yield) .
With the rapid development of chemical substances, we look forward to future research findings about 31462-58-5.
Reference:
Patent; ABBVIE INC.; ABBVIE PHARMACEUTICAL TRADING (SHANGHAI) CO., LTD.; FIDANZE, Steven D.; LIU, Dachun; MANTEI, Robert A.; MCDANIEL, Keith F.; PRATT, John; SHEPPARD, George S.; WANG, Le; BOGDAN, Andrew; HOLMS, James H.; DIETRICH, Justin D.; MARJANOVIC, Jasmina; HASVOLD, Lisa A.; DAI, Yujia; WO2014/139324; (2014); A1;,
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