Reference of 3270-97-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 3270-97-1 as follows.
(Essigsaeure=acetic acid) To a stirred solution of 7.0 g (0.05 mol) 6-methoxy-2,4-diaminopyrimidine in 100 ml acetic acid (10% conc. in water) at 50-60 C. was added dropwise over a period of 30 min a solution of 4.55 g (0.07 mol) sodium nitrite in 20 ml water. The solution was stirred at this temperature for a further 30 min and then stirred at room temperature overnight. The filtrate was filtered off with suction, washed with water and dried. 5-Nitroso-2,4-diamino-6-methoxypyrimidine (7.80 g, 92%) was obtained as a violet solid. m.pt.: 250 C. (dec.) 1H-NMR (300 MHz, d6-DMSO): delta=4.04 (s, 3 H, 6-OMe), 7.79 (s,1H, NH2), 7.85 (s,1H, NH2), 8.01 (s,1H, NH2), 10.10 (s, 1H, NH2). 13C-NMR (125 MHz, d6-DMSO): delta=54.5 (6-OMe), 140.0 (5-C), 151.2 (2-C), 163.8 (4-C), 171.4 (6-C).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3270-97-1, its application will become more common.
Reference:
Patent; Gebert, Antje; Giesa, Helmut; Koenen, Annika; US2015/209257; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
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