Extended knowledge of 33034-67-2

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 33034-67-2, 2-Chloro-4-(trifluoromethyl)pyrimidine.

Related Products of 33034-67-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 33034-67-2, name is 2-Chloro-4-(trifluoromethyl)pyrimidine, molecular formula is C5H2ClF3N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a mixture of 48 mg of potassium carbonate in methanol (3 ml) was added 37 mg of 4-(5- cyano-7-isopropyl-l ,3-benzoxazol-2-yl)-N-[(7S)-l ,4-oxazepan-7-ylmethyl]benzamide(INTERMEDIATE 20) followed by 2-chloro-4-(trifluoromethyl)pyrimidine (16 mg). The mixture was heated via microwave at 12O0C for 35 min, and then cooled and added directly to a 4OM samplet for purification via column chromatography on a Biotage Horizon 4OM column, eluting with 1 column volume of 100percent hexanes, followed by a gradient of 0 to 100percent ethyl acetate in hexanes over 10 column volumes, followed by 4 column volumes of 100percent ethyl acetate, to provide the title compound (37 mg, 76 percent). Mass spectrum (ESI) 565.2 (M+l). 1H NMR (500 MHz, CDCl3): delta 8.52 (s, IH), 8.35 (d, J=8.5 Hz, 2H), 7.96 (d, J=8.3 Hz, 2H), 7.95 (s, IH), 7.54 (s, IH), 6.81 (d, J=4.8 Hz, IH), 6.65 (bs, IH), 4.26 (m, 2H), 3.98 (m, 3H), 3.70 (s, 2H), 3.69 (m, 2H), 3.48 (sept, J=7.0 Hz, IH), 3.25 (m, IH), 2.19 (m, IH), 1.83 (m, IH), 1.48 (d, J=7.1 Hz, 6H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 33034-67-2, 2-Chloro-4-(trifluoromethyl)pyrimidine.

Reference:
Patent; MERCK & CO., INC.; WO2008/156715; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia