As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3764-01-0, name is 2,4,6-Trichloropyrimidine, molecular formula is C4HCl3N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: 2,4,6-Trichloropyrimidine
2,4,6-trichloropyrimidin (10g, 54.51mmol), phenylboronic acid (16.6g, 136,29mmol), Pd(PPh3)4 (3.15g, 2.72mmol), 2M K2CO3 (50ml), toluene (100ml) and ethanol (30ml)were mixed and stirred under reflux. 4 hours later, the mixture was cooled room temperature, distilled water was added. After extracting with EA and drying with anhydrous MgSO4, distillation under reduced pressure followed by column separation yielded Compound 2-1 (7g, 26.24mmol, 48.14%).
With the rapid development of chemical substances, we look forward to future research findings about 3764-01-0.
Reference:
Patent; ROHM AND HAAS ELECTRONIC MATERIALS KOREA LTD.; KIM, Chi Sik; EUM, Sung Jin; CHO, Young Jun; KWON, Hyuck Joo; KIM, Bong Ok; KIM, Sung Min; YOON, Seung Soo; WO2011/10839; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia