Electric Literature of 3764-01-0 , The common heterocyclic compound, 3764-01-0, name is 2,4,6-Trichloropyrimidine, molecular formula is C4HCl3N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of 2,4,6-trichloropyrimidine (100 mg, 0.55 mmol) in tetrahydrofuran (4 mL) were added tetrakis(triphenylphosphine)palladium (43 mg, 0.05 mmol), furan-2-ylboronic acid (61 mg, 0.55 mol) and an aqueous sodium carbonate solution (1 M, 1.64 mL, 1.64 mmol). The mixture was heated to 80°C and stirred overnight. To the reaction mixture was added water (50 mL), and the mixture was extracted with EtOAc (50 mL x 3). The combined organic layers were washed with saturated brine (50 mL), dried over anhydrous sodium sulfate, and filtered. The filtrate was concentrated in vacuo to dry,and the residue was purified by silica gel column chromatography (PE) to give the title compound as a yellow solid (42 mg, 3 6percent).MS (ESI, pos.ion) m/z: 215.0 [M+Hfb; ?H NMR (400 MFIz, CDC13) (ppm):7.67 (d, J= 0.7 Hz, 1H), 7.58 (s, 1H), 7.43 (d, J= 3.4 Hz, 1H), 6.65 (dd, J 3.4, 1.6 Hz, 1H).
The synthetic route of 3764-01-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; REN, Qingyun; TANG, Changhua; YIN, Junjun; YI, Kai; ZHANG, Yingjun; (264 pag.)WO2018/33082; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia