Application of 137281-39-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 137281-39-1, name is 4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoic acid, molecular formula is C15H14N4O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
10.00 g of acid (2) from the example 4 are added at room temperature to 90ml of ethanol, 40 ml of water and 8.83 g of 2-chloro-4,6-dimethoxy-1 ,3,5-triazine(CDMT).A mixture consisting of 21.1 g NaOH, 20 ml of water and 10.3 ml of N-10 methyl morpholine was first added to the suspension obtained and then 10,45 g ofdiethyi-L-glutamate hydrochloride.The reaction mixture is kept under stirring at 40C for 3 hours and is filteredon a bed consisting of 0,48 g of activated carbon and 0:48 g of Celite. Afterwashing the filter with 20 ml of ethanol/water mixture 3/2, the filtrate is heated to15 40C and added to 49 ml of water and 55 ml of Acetone.The mixture is then cooled to room temperature and after cooling to ooc for1 hour, the suspension obtained is filtered, the solid washed with 80 ml ofwater/acetone mixture 3/1 and with 80 ml of Acetone. The solid is then dried undervacuum at 50C. 14:25 g of diethyl ester of pemetrexed (3) as a cream-colored20 solid (yield 93.5%) are obtained.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 137281-39-1, 4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoic acid.
Reference:
Patent; BERLIN-CHEMIE AG; BONACCORSI, Fabrizio; CALVANI, Federico; PASQUI, Franco; WO2014/24164; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia