Extended knowledge of 4-Chloro-7-cyclopentyl-5-iodo-7H-pyrrolo[2,3-d]pyrimidine

At the same time, in my other blogs, there are other synthetic methods of this type of compound,213745-17-6, 4-Chloro-7-cyclopentyl-5-iodo-7H-pyrrolo[2,3-d]pyrimidine, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 213745-17-6, 4-Chloro-7-cyclopentyl-5-iodo-7H-pyrrolo[2,3-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 213745-17-6, blongs to pyrimidines compound. SDS of cas: 213745-17-6

To a pressure tube with dioxane (5 mL) was added 4-Chloro-7-cyclopentyl-5-iodo-7H- pyrrolo [2, 3-D] PYRIMIDINE, then ammonia hydroxide (5 mL). The pressure tube was sealed and heated at 120C overnight. All solvents were removed via reduced pressure, and the residue were purified through flash COLUMN (METHYLENE CHLORIDE/METHANOL : 97/3). The product was obtained as a white solid (300 mg, 92%). MS: 329.1 (MH+); HPLC Rf: 5.018 min.; HPLC purity: 99%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,213745-17-6, 4-Chloro-7-cyclopentyl-5-iodo-7H-pyrrolo[2,3-d]pyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; PFIZER PRODUCTS INC.; WO2004/56830; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia