Electric Literature of 54660-78-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.54660-78-5, name is 4-Chloropyrimidin-5-amine, molecular formula is C4H4ClN3, molecular weight is 129.5477, as common compound, the synthetic route is as follows.
Step 1 : To a 50mL round -bottom flask was added 20mL 1, 4-Dioxane, compound 5a (885mg, 6.83mmol, l .Oeq), compound lb (1.61g, 7.52mmol, l. leq) and DIPEA (1.32g, 10.25mmol, 1.5eq). The reaction was heated to reflux for 18h. TLC (PE: EA= 1 : 1) showed the reaction was completed. The reaction mixture was concentrated in vacuum and purified by column chromatography on silica gel eluted with PE: EA= 3 : 1- 1 : 1 to afford the title compound 5b (1.5g, HPLC: 93%, Yield: 71.4%) as an orange solid.
The chemical industry reduces the impact on the environment during synthesis 54660-78-5, I believe this compound will play a more active role in future production and life.
Reference:
Patent; LIANG, Congxin; (62 pag.)WO2018/5713; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia