Reference of 199678-12-1 , The common heterocyclic compound, 199678-12-1, name is 4-Pyrimidin-2-yl-benzoic acid, molecular formula is C11H8N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a mixture of compound 3 (2g, lOmmol), EDCI (2.3g, l2mmol), HOBT(1 .4g, 1 Ommol), DIEA (2. 6g, 2Ommol) and N,O-dimethylhydroxylamine hydrochloride(1.2g, l2mmol) in DCM, stirred at RT for 2h. Water was added and extracted withDCM. The extracts were concentrated to give 2.5g of compound 4.
The synthetic route of 199678-12-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; FORGE LIFE SCIENCE, LLC; REMISZEWSKI, Stacy; KOYUNCU, Emre; SUN, Qun; CHIANG, Lillian; (98 pag.)WO2016/77232; (2016); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia