Related Products of 4316-97-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4316-97-6, name is 4,6-Dichloro-5-methylpyrimidine. A new synthetic method of this compound is introduced below.
1 -(6-Chloro-5-methylpyrimidin-4-yl)-2,3-dihvdro-1 H-imidazon ,2- blpyrazoleTo a solution of 2,3-dihydro-1 H-imidazo[1 ,2-b]pyrazole (Preparation 12) (14.1 g, 129 mmol) and 4,6-dichloro-5-methylpyrimidine (21.1 g, 129 mmol) in 800 mL of tetrahydrofuran cooled down to zero degrees Celsius was added sodium bis(trimethylsilyl)amide (1 M in tetrahydrofuran, 138 ml_, 138 mmol) drop-wise over 1 hour. After 2 hours, water was added and tetrahydrofuran evaporated. Dichloromethane was then added and the aqueous phase was extracted 3 times with dichloromethane. The combined organic layers were dried over magnesium sulfate, filtered and the filtrate was concentrated in vacuo. The residue was dissolved in a minimum amount of dichloromethane and the desired product was precipitated using heptane. The resulting solid was filtered, washed with heptane and dried under vacuum to give 24.6g (90% yield) of a beige solid. LCMS (ES+): 236.3 (M+1 ).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4316-97-6, its application will become more common.
Reference:
Patent; PFIZER INC.; MASCITTI, Vincent; MCCLURE, Kim Francis; MUNCHHOF, Michael John; ROBINSON, Ralph Pelton; WO2011/61679; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
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