Adding a certain compound to certain chemical reactions, such as: 57054-92-9, 5-Bromo-2-chloro-4-methoxypyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 57054-92-9, blongs to pyrimidines compound. Product Details of 57054-92-9
To a mixture of (1S,2R)-2-(4-amino-3-cyclopropyl-pyrazol-1-yl)cyclopropanecarbonitrile (0.1 g, 531.27 mumol) and 5-bromo-2-chloro-4-methoxy-pyrimidine (119 mg, 531.27 mumol) in 1,4-dioxane (2 mL) was added p-TsOH.H2O (30 mg, 159.38 mumol) at 20 C. under N2. The mixture was stirred at 85 C. for 4 h. The mixture was poured into aq. NaHCO3 (5 mL) and extracted with EtOAc (3*5 mL). The combined organic phase was washed with brine (10 mL), dried with anhydrous Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (PE:EtOAc=100:1 to 1:1) and separated by SFC to give (1S,2R)-2-[4-[(5-bromo-4-methoxy-pyrimidin-2-yl)amino]-3-cyclopropyl-pyrazol-1-yl]cyclopropanecarbonitrile and (1R,25)-2-[4-[(5-bromo-4-methoxy-pyrimidin-2-yl)amino]-3-cyclopropyl-pyrazol-1-yl]cyclopropanecarbonitriles
At the same time, in my other blogs, there are other synthetic methods of this type of compound,57054-92-9, 5-Bromo-2-chloro-4-methoxypyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; Denali Therapeutics Inc.; Estrada, Anthony A.; Feng, Jianwen A.; Lyssikatos, Joseph P.; Sweeney, Zachary K.; de Vicente Fidalgo, Javier; (79 pag.)US2017/362206; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia