Synthetic Route of 5751-20-2, Adding some certain compound to certain chemical reactions, such as: 5751-20-2, name is 2-(Methylthio)pyrimidin-4(3H)-one,molecular formula is C5H6N2OS, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5751-20-2.
Preparation of 2-(3-chlorophenylamino)pyrimidin-4(3H)-one (2); To 2-(methyl-thio)pyrimidine-4(3H)-one, 1, (4.88 g, 34.37 mmol) in diglyme (20 mL) is added 3-chloroaniline (4.3 mL, 68.74 mmol). The resulting mixture is heated to reflux and stirred for 18 hours. A solid forms upon cooling the mixture to room temperature. The solid is washed with hexanes to afford 5.0 g (66percent yield) of the desired compound. 1H NMR (DMSO-d6, 300 MHz): delta 5.91 (d, J=5.7 Hz, 2H), 7.05 (d, J=7.5 Hz, 1H), 7.11 (br s, 1H), 7.32 (t, J=7.8, 15.9 Hz, 1H), 7.45 (d, J=7.8 Hz, 1H), 7.86 (d, J=4.5 Hz, 1H), 7.94 (s, 1H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 5751-20-2, 2-(Methylthio)pyrimidin-4(3H)-one, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Djung, Jane Far-Jine; Golebiowski, Adam; Hunter, Jack A.; Shrum, Gary P.; US2007/293494; (2007); A1;; ; Patent; DJUNG, Jane Far-Jine; Golebiowski, Adam; Hunter, Jack A.; Shrum, Gary P.; US2007/293525; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
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