In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 580-17-6, name is 3-Aminoquinoline belongs to quinolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 3-Aminoquinoline
General procedure: To an oven-dried 100 mL three-necked round-bottomed flask equipped with two glass stoppers, a vacuum-jacketed Dean-Stark trap topped with a reflux condenser fitted with a N2 inlet, and a Teflon-coated magnet stirring bar were placed pyridin-3-amine (0.5 g, 5.3 mmol), boric acid (0.1 g, 1.6 mmol), and mesitylene (70 mL). To the stirred reaction mixture were added N,N,N’,N’-tetramethylpropane-1,3-diamine (0.21 g, 1.6 mmol) and 8-methoxy-8-oxooctanoic acid (1.5 g, 8 mmol) in one portion. The stirred reaction mixture was heated at gentle reflux at ca. 164 C for 7 h. TLC analysis (eluent: EtOAc) indicated the complete disappearance of the amine starting material. After cooling to r.t., the mixture was poured into petroleum ether (350 mL) leading to the immediate precipitation of an off-white solid. Stirring was continued for an additional 30 min and the precipitate was then filtered through a sintered glass funnel. The collected solid was thoroughly washed with petroleum ether and H2O, and dried in vacuo at r.t. for 24 h, then purified by flash chromatography to afford methyl 8-oxo-8-(pyridin-3-ylamino)octanoate as an off-white solid; yield: 1.14 g (82%); mp 52.6-53.4 C.
The synthetic route of 580-17-6 has been constantly updated, and we look forward to future research findings.