Synthetic Route of 58347-49-2, Adding some certain compound to certain chemical reactions, such as: 58347-49-2, name is 7-Chloropyrazolo[1,5-a]pyrimidine,molecular formula is C6H4ClN3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 58347-49-2.
A solution of 7-chloropyrazolo[l,5-ajpyrimidine (0.1 g, 0.651 mmol), 6-bromo-2-(difluoromethyl)-3 -fluoropyridine (0.162 g, 0.716 mmol) and 1,1,1,2,2,2-hexamethyldistannane (0.235 g, 0.7 16 mmol) in 1,4-dioxane (2 mL) was purged with nitrogen gas for 10 mi Pd(Ph3P)4 (0.075 g, 0.065 mmol) was added to the reaction mixture and the solution was purged with nitrogen gas for another 10 mm. The reaction mixture was heated at 150 C for 1.5 h. The reaction mixture was cooled to room temperature and concentrated under reduced pressure. The residue waspurified by silica-gel chromatography (pet ether/ethyl acetate (0-40%)) to afford 7- (6-(difluoromethyl)-5-fluoropyridin-2-yl) pyrazolo [1,5-al pyrimidine (40 mg, 0.151 mmol, 23% yield) as a yellow solid .LCMS (ESI) m/e 265.0 [(M+H), calcd for C12H8F3N4 265.11; LC/MS retention time (Method Al): tR = 2.08 mm.
According to the analysis of related databases, 58347-49-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; BRONSON, Joanne J.; CHEN, Ling; DITTA, Jonathan L.; DZIERBA, Carolyn Diane; JALAGAM, Prasada Rao; LUO, Guanglin; MACOR, John E.; MAISHAL, Tarun Kumar; NARA, Susheel Jethanand; RAJAMANI, Ramkumar; SISTLA, Ramesh Kumar; THANGAVEL, Soodamani; (318 pag.)WO2017/59080; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
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