Electric Literature of 353272-15-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.353272-15-8, name is 6-Chloro-5-iodopyrimidin-4-amine, molecular formula is C4H3ClIN3, molecular weight is 255.4442, as common compound, the synthetic route is as follows.
To a mixture of 6-chloro-5-iodopyrimidin-4-am.ine (500 mg, 0.196 mmol), Pd(PPh3)2Cl2 (69 mg, 0.10 mmol ) and Cul (19 mg, 0.10 mmol) under 2 atmosphere were added a solution of etiiynyltrimethylsilane (1 ,38 mL, 9.79 mmol) in DMF (1.5 mL) and a solution triethylamine (0.54 mL, 3.91 mmol) in DMF (1.5 mL), The resulted mixture was heated to 47 C and stirred further for 2 hours. The mixture was diluted with EtOAc (30 mL), and the resulted mixture was washed with water (20 mL x 2) and brine (20 mL). The separated organic phase was dried over anhydrous Na2S04 and concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (v/v) ::: 10/1) to give the title compound as a brown solid (442 mg, yield 100%). MS (ESI, pos. ion) m/z: 226.0 [M+H]+; NMR (400 MHz, CDCb) delta (ppm): 8.31 (s, 1H), 5.62 (s, 2H), 0.31 (s, 9H).
Statistics shows that 353272-15-8 is playing an increasingly important role. we look forward to future research findings about 6-Chloro-5-iodopyrimidin-4-amine.
Reference:
Patent; CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.; XI, Ning; WANG, Liang; WANG, Tingjin; WU, Weibin; (123 pag.)WO2015/175579; (2015); A1;,
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