Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 31058-83-0, name is 6-Chloro-N,N-dimethylpyrimidin-4-amine. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 31058-83-0
Example 33: N.N-Dimethyl-e-KIS.eRVe-tP-iS-methyl-l ^^-oxadiazol-S- l)phenyl]carbonyl}-3,8-diazabicyclo[4.2.0]oct-3-yl]pyrimidin-4-amine.A mixture of Intermediate 12 (50 mg, 0.17 mmol), 2-chloro-4,6- dimethylpyrimidine (24 mg, 0.17 mmol) and DIPEA (0.87 mL, 0.5 mmol) in ACN (1 mL) was heated in the microwave at 200 C for 2 h. The mixture was concentrated in vacuo and chromatography (Hex to 100% EtOAc/Hex) to afford the desired product as a pale yellow foam (39 mg, 55%). MS (ESI) mass calculated for C22H25N7O2, 419.2; m/z found, 420.2. 1 H NMR (500 MHz, CDCI3): 8.15 (s, 1 H), 8.12 – 8.04 (m, 1 H), 7.59 – 7.50 (m, 2H), 7.25 – 7.17 (m, 1 H), 5.22 (s, 1 H), 4.44 – 4.33 (m, 2H), 4.1 1 – 3.99 (m, 1 H), 3.94 – 3.73 (m, 2H), 3.68 – 3.60 (m, 1 H), 3.1 1 – 3.05 (m, 6H), 3.02 – 2.86 (m, 2H), 2.45 – 2.42 (m, 3H), 2.22 – 1 .97 (m, 2H).
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Reference:
Patent; JANSSEN PHARMACEUTICA NV; BRANSTETTER, Bryan, James; LETAVIC, Michael, A.; LY, Kiev, S.; RUDOLPH, Dale, A.; SAVALL, Brad, M.; SHAH, Chandravadan, R.; SHIREMAN, Brock, T.; WO2011/50202; (2011); A1;,
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