Synthetic Route of 659729-09-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 659729-09-6, name is 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.
1.27 g (4.92 mmol) of 4-chloro_6_ (4′-trifluoromethylphenyl) pyrimidine was weighed out,(0.85 g, 5.18 mmol) of trimethylbenzeneboronic acid,4 g of tetrakis (triphenylphosphine) palladium and 3 g of anhydrous sodium carbonate were placed in a 120 mL sealed tube,A mixture of tetrahydrofen sitan 30 mL and 20 mL of deionized water was placed in a sealed tube as a solvent, and a stirrer was added and the stopper was capped.The entire device vacuum nitrogen nitrogen replacement 3 ~ 4 times, placed in the oil bath pot,The mixture was heated to 115 C on a magnetic stirrer and refluxed for about 8 h.After the reaction,Sealed to cool to room temperature, the solution inside the sealed tube into the rotary bottle,The tetrahydrofuran solvent was distilled off under reduced pressure by rotary evaporator.The organic product was extracted with ethyl acetate and water for 3 to 4 times. The solvent was distilled off under reduced pressure. The spheroidized product was separated by petroleum ether: ethyl acetate 20: 1,To give a pale yellow solid, about 0.87 g, yield 51.6%.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 659729-09-6, 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine.
Reference:
Patent; Anhui University of Technology; Tong Bihai; He Yuheng; Liu Yuanyuan; Jin Long; Zuo Dashuai; Wang Song; (25 pag.)CN106632488; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia