Synthetic Route of 62458-96-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 62458-96-2, name is 7-Benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one. A new synthetic method of this compound is introduced below.
To 7-benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one (Step A, 1.50 g, 6.22 mmol) in toluene (25 mL) were sequentially added DIPEA (0.87 mL, 5.0 mmol) and POCl3 (0.70 mL, 7.46 mmol). The contents were heated at 105 C. for 2 hour, cooled to rt, diluted with dichloromethane (100 mL) and stirred with cold aq. sat’d NaHCO3 (150 mL) for 1 h. The dichloromethane layer was dried over sodium sulfate and concentrated under reduced pressure to afford the title compound b (1.61 g) as a dark oil. LCMS [M+H]+ 260.08.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,62458-96-2, its application will become more common.
Reference:
Patent; Bristol-Myers Squibb Company; US2008/275052; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia