Synthetic Route of 89793-12-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.89793-12-4, name is Ethyl 2-chloropyrimidine-5-carboxylate, molecular formula is C7H7ClN2O2, molecular weight is 186.6, as common compound, the synthetic route is as follows.
A mixture of aniline (3.7 g, 40 mmol), compound 1 (7.5 g, 40 mmol), and K2C03 (11 g, 80 mmol) in DMF (100 ml) was degassed and stirred at 120 C under N2 overnight. The reaction mixture was cooled to r.t. and diluted with EtOAc (200 ml), then washed with saturated brine (200 ml chi 3). The organic layers were separated and dried over Na2S04, evaporated to dryness and purified by silica gel chromatography (petroleum ethers/EtOAc = 10/1) to give the desired product as a white solid (6.2 g, 64 %).
Statistics shows that 89793-12-4 is playing an increasingly important role. we look forward to future research findings about Ethyl 2-chloropyrimidine-5-carboxylate.
Reference:
Patent; ACETYLON PHARMACEUTICALS, INC.; NORTH, Brian; QUAYLE, Steven; (56 pag.)WO2018/81585; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
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