Synthetic Route of 923282-39-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.923282-39-7, name is 7-Chloro-1-methyl-1H-pyrazolo[4,3-d]pyrimidine, molecular formula is C6H5ClN4, molecular weight is 168.58, as common compound, the synthetic route is as follows.
Compound 10: To a solution of 3 (0.33 g, 1.0 mmol) and Hunig’s base (0.52 mL, 3.0 mmol) in 3 mL of DMF was added 9 (0.169 g, 1.0 mmol). The resulting mixture was heated and stirred at 90 C. for 1 hour. After the reaction was cooled to room temperature, water was added and washed with ethyl acetate (×3). The combined organics were washed with brine, dried (MgSO4), and concentrated under reduced pressure. The crude residue was purified by prep RP-HPLC. The fractions containing pure compound were consolidated and concentrated. The residue thus obtained was lyophilized under high-vacuum to yield 10 (59 mg, 9%) as the bis TFA salt. 1H NMR (d6-DMSO) delta 3.10-3.13 (m, 2H) 3.90-3.92 (m, 2H) 4.33 (s, 3H) 7.19 (s, 1H) 7.36 (m, 1H) 7.51-7.55 (m, 1H) 7.62-7.64 (m, 1H) 8.01 (s, 1H) 8.16 (s, 1H) 8.72 (s, 1H) 9.02 (bs, 1H) 9.57 (s, 1H); ES (+) MS m/e=463 (M+1).
Statistics shows that 923282-39-7 is playing an increasingly important role. we look forward to future research findings about 7-Chloro-1-methyl-1H-pyrazolo[4,3-d]pyrimidine.
Reference:
Patent; Sunesis Pharmaceuticals, Inc.; US2007/27166; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia