Synthetic Route of 932-52-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 932-52-5 as follows.
8-(2,6-Difluorophenyl)-4-(4-fluoro-2-methlphenyl)-2-(N-aminouracil-5-yl)-8H-pyrido[2,3-d]pyrimidin-7-one The title compound of Example 48 [8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylphenyl)-2-methanesulfonyl-8H-pyrido[2,3-d]pyrimidin-7-one] (100 mg, 0.000225 mol) and 5-aminouracil (70 mg, 0.00055 mol) were taken up in dry DMSO (1.5 ML) and, with stirring under Ar, warmed to 65 for 6.5 h.Reaction was cooled to 23, then diluted with EtOAc; solution was washed with H2O; the aq phase was extracted with EtOAc; combined organic layers were dried (Na2SO4) then evaporated to an amber glass.This glass was crystallized from a small amount of MeOH, which crystals when dried afforded 15 mg (14%) of the title compound as a light yellow crystalline solid. (m.p.>300) LC MS (m/e)=493(MH+). Rt=1.82 min.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,932-52-5, its application will become more common.
Reference:
Patent; Adams, Jerry L.; Boehm, Jeffrey C.; Hall, Ralph; Jin, Qi; Kasparec, Jiri; Silva, Domingos J.; Taggart, John J.; US2004/116697; (2004); A1;,
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