As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 956034-07-4, name is 2,4-Dichlorofuro[3,2-d]pyrimidine, molecular formula is C6H2Cl2N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Quality Control of 2,4-Dichlorofuro[3,2-d]pyrimidine
Step A: 2-Chloro-/V-(2,2-difluoroethyl)furo[3,2-i/|pyrimidin-4-amineTo a flask was added 2,4-dichlorofuro[3,2-i/]pyrimidine (2 g, 10.58 mmol, Arkpharm), DCM (20 mL) and TEA (2.95 mL, 21.16 mmol). A solution of 2,2-difluoroethanamine (0.858 g, 10.6 mmol, Matrix) in DCM (5 mL) was added drop-wise and the mixture was stirred at rt overnight. The mixture was concentrated under reduced pressure. To the residue was added 1,4-dioxane (20 mL), TEA (2.95 mL, 21.2 mmol) and a solution of 2,2-difluoroethanamine (0.858 g, 10.58 mmol, Matrix) in 1,4-dioxane (5 mL). The mixture was stirred at rt for about 4 h, and then at about about 55 C overnight. The mixture was concentrated under reduced pressure, and the residue was taken up in EtOAc (120 mL) and water (25 mL). The organic layer was isolated and washed with water (2 x 25 mL). The combined aqueous layers were washed with EtOAc (2 x 25 mL). The combined organic layers were washed with brine (25 mL), dried with MgS04, filtered, concentrated under reduced pressure, and dried in a vacuum oven at about 70 C over 2 days to give 2-chloro-^-(2,2-difluoroethyl)furo[3,2-i/]pyrimidin-4-amine (2.20 g, 89 %): LC/MS (Table 2, Method c) R, = 1.69 min.; MS m/z: 234 (M+H)+.
With the rapid development of chemical substances, we look forward to future research findings about 956034-07-4.
Reference:
Patent; ABBOTT LABORATORIES; CALDERWOOD, David, J.; WILSON, Noel, S.; COX, Philip; HOEMANN, Michael, Z.; CLAPHAM, Bruce; MULLEN, Kelly, D.; VASUDEVAN, Anil; VILLAMIL, Clara I; LI, Bin; SOMAL, Gagandeep; WO2012/48222; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia