Synthetic Route of 89581-38-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 89581-38-4, name is Methyl 5-bromopyrimidine-2-carboxylate, molecular formula is C6H5BrN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
j0445j To a round bottom flask were added sequentially methyl 5-bromopyrimidine-2- carboxylate (0.83 g, 3.82 mmol), di-tert-butyl( (3,6-dimethoxy-2-[2,4,6-tris(propan-2- yl)phenyl]phenyl})phosphane (0.02 g, 0.04 mmol) and caesium carbonate (1.74 g, 5.35 mmol). These solids were mixed, then evacuated under vacuum and purged with nitrogen three times. Methanol (0.61 g, 19.12 mmol) was then added to this flask via a syringe. lila separate flask was weighed methanesulfonato(2-(di-tert-butylphosphino)-3 ,6-dimethoxy- 2?,4?,6?-tri-i-propyl- 1,1 Lhiphenyl)(2?amino_1, I ?-biphenyl-2-yl)palladium(II) (0.03 g, 0.04 mmol), which was evacuated and purged with nitrogen twice. Dioxane (3.8 mL) was added to this flask and the flask agitated until a greenish solution resulted; this solution was then transferred via syringe to the first flask. The resulting reaction mixiure was heated to 50 C for 4 hours. The reaction mixture was cooled, diluted with ethyl acetate and filtered. The velatiles were evaporated and the residue purified by FCC (silica, 50-100% ethyl acetate in heptane) to give the title compound 0.25 g (32% yield) as an off-white solid. SH NMR (500 MHz, Chloroform) X.54 (s, 2H), 4M5 (s, 3H), 4AM (s, 3H). Tr(METCR1673) = 0.48 mm, (ESj (M–H) 169.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 89581-38-4, Methyl 5-bromopyrimidine-2-carboxylate.
Reference:
Patent; CHDI FOUNDATION, INC.; DOMINGUEZ, Celia; WITYAK, John; BARD, Jonathan; KISELYOV, Alex; BROWN, Christopher, John; GALAN, Sebastien, Rene Gabriel; PRIME, Michael, Edward; GILES, Paul, Richard; GADOULEAU, Elise, Luciennen Paulette; KRUeLLE, Thomas, Martin; CLARK-FREW, Daniel; JOHNSON, Peter, David; SCHAERTL, Sabine; HERRMANN, Frank; GRIMM, Steffen, Kaspar; KAHMANN, Jan, Dirk; SCHEICH, Christoph; COE, Samuel; HAYES, Sarah; (271 pag.)WO2016/33445; (2016); A1;,
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