Electric Literature of 1421372-94-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1421372-94-2, name is N-(4-Fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine, molecular formula is C20H16FN5O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
in room temperature,801 ml of N, N-dimethylacetamide was added to a 2 L reaction flask,80.1 g of the compound represented by the formula (II)20.6 g of N, N, N’-trimethylethylenediamine,28.1 grams of potassium carbonate. The mixture was heated at 110 C,Reaction for 7 hours. Slow down to 25 ~ 28 ,Slowly add 801 ml of water,Starch crystallization for 1 hour.Filter,The filter cake was washed with 160 ml of water Polyester.Filter cake into the vacuum drying oven,To give 92.8 grams of orange-red solid,Yield: 95.9%
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1421372-94-2, N-(4-Fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine.
Reference:
Patent; Luoxin Bio-technology (Shanghai) Co., Ltd.; Shandong Luoxin Pharmaceutical Group Co., Ltd.; Pan Longgang; Cai Zhengyuan; Li Guoliang; Yang Wenqian; Wang Tielin; (10 pag.)CN107188888; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia