As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13223-25-1, name is 2-Chloro-4,6-dimethoxypyrimidine, molecular formula is C6H7ClN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Product Details of 13223-25-1
This example is used to describe the pyrimidine salicylic acid compounds of the present invention and processes for their preparation.1 mmol of Compound A was dissolved in 30 mL of re-evaporated toluene, 2 mmol of potassium carbonate was added, reacted at 20 C for 2 hours, 4,6-dimethoxy-2-methylsulfonylpyrimidine (1 mmol) was added and reacted at 120C for 12 h. The solvent was distilled off under reduced pressure, and a small amount of water was added to completely dissolve the solid. The aqueous layer was washed with ether several times. The aqueous layer was acidified with concentrated hydrochloric acid to pH=1, extracted with dichloromethane, dried over anhydrous sodium sulfate, Acid compound A1. The yield of compound A1 from compound A was 78% This example is used to describe the pyrimidine salicylic acid compounds of the present invention and processes for their preparation. The pyrimidine salicylic acid compound was prepared according to the method of Example 1, Except that 4,6-dimethoxy-2-methylsulfonylpyrimidine was replaced by 4,6-dimethoxy-2-chloropyrimidine to give pyrimidine salicylic acid compound A1. The yield of compound A1 from compound A was 15%.
With the rapid development of chemical substances, we look forward to future research findings about 13223-25-1.
Reference:
Patent; HUAZHONG NORMAL UNIVERSITY; YANG, GUANGFU; LIU, YUCHAO; CHEN, QIONG; CHEN, JIE; CUI, HAILAN; TANG, WEI; (17 pag.)CN104140397; (2016); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia