Extracurricular laboratory: Synthetic route of 1-(2-Chloropyrimidin-4-yl)ethanone

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1312535-78-6, 1-(2-Chloropyrimidin-4-yl)ethanone, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1312535-78-6, name is 1-(2-Chloropyrimidin-4-yl)ethanone, molecular formula is C6H5ClN2O, molecular weight is 156.5697, as common compound, the synthetic route is as follows.HPLC of Formula: C6H5ClN2O

Step 1 : l-(2-chloropyrimidin-4-yl)ethanone (1 eq) is disolved in HBr/HOAc(1 mL/ mmol) and E¾ (1.1 eq) is added drop wise. The reaction mixture is stirred for 1 hour at room temperature, ether (10 mL/mmol) was added and the mixture was cooled at 0 C. The solid is collected by filtration to afford 2-bromo-l-(2-chloropyrimidin-4-yl)ethanone.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1312535-78-6, 1-(2-Chloropyrimidin-4-yl)ethanone, and friends who are interested can also refer to it.

Reference:
Patent; SELEXAGEN THERAPEUTICS, INC.; VERNIER, Jean-michel; HOPKINS, Stephanie; BOUNAUD, Pierre-Yves; O’CONNOR, Patrick; MATTHEWS, David; BENDER, Steve; WO2012/125981; (2012); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia