As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1005-37-4, name is 6-Chloro-N4-methylpyrimidine-2,4-diamine, molecular formula is C5H7ClN4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: 6-Chloro-N4-methylpyrimidine-2,4-diamine
Example 3296-[4-(Aminomethyl)phenyl]-4-N-methylpyrimidine-2,4-diamine.Tetrakis(triphenylphosphine)palladium (0) (5 mol%) was added to a stirredmixture of 6-chloro-4-N-methylpyrimidine-2,4-diamine (1.00 mmol), [4-(aminomethyl)phenyl]boronic acid (1.3 eq.), sodium carbonate (4.2 eq.), dioxane(4 ml) and water (1 ml) in a tube. The tube was sealed and the reaction washeated at 90C overnight. The solvent were removed in vacuum and to theremaining solid was added ethyl acetate and washed with water. The organic phase was dried over magnesium sulfate. The crude material was then purified by flash chromatography (0-*15 % MeOH/DCM) to give the title compound. LCMS [M+H] 230; 1H NMR (400 MHz, DMSO-d6) OH ppm 7.86 (2 H, d, J=7.58Hz), 7.38 (2 H, d, J=8.59 Hz), 6.19 (1 H, 5), 5.96 (2 H, 5), 3.76 (2 H, 5), 2.79 (3 H, d, J=4.80 Hz).
With the rapid development of chemical substances, we look forward to future research findings about 1005-37-4.
Reference:
Patent; THOMAS HELLEDAYS STIFTELSE FOeR MEDICINSK FORSKNING; SCOBIE, Martin; HELLEDAY, Thomas; KOOLMEISTER, Tobias; JACQUES, Sylvain; DESROSES, Matthieu; JACQUES-CORDONNIER, Marie-Caroline; WO2014/84778; (2014); A1;,
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